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Permix High Shear granulators

PERMIX HIGH SHEAR GRANULATOR

permix high shear granulators - general description

High shear granulators consists of a cylindrical or conical mixing bowl, a three-bladed impeller, a chopper, an auxiliary chopper, a motor to drive the blades and a discharge pot. By either circulating hot or cool liquid or steam through the jacket, the mixing bowl is jacketed for heating or cooling the contents of the bowl as the case may be.  


The high-shear wet granulation process using high-shear granulator can be divided into 5 stages and they included; 

•Powder mixing 

•Binder addition or addition of granulating liquid. 

•Wetting of powder and nucleation 

•Growth of granules and densification of the powder. 

•Granule attrition and breakage.  


The impeller which is employed in mixing of the dry powder and spreading of the granulating fluid in high-shear granulator normally rotates at a speed ranging from 100rpm to 500rpm. The chopper forms part of high-shear granulator and is used to break down the wet lump to produce granules. The chopper rotates at a speed of 1000 to 3000rpm. Powder densification and/or agglomeration are by the in cooperation of a granulation fluid into the powder with high-power-per-unit mass, through rotating high-shear forces. #permix

High shear granulators - categories

High shear granulators can be subclassified into vertical high shear granulator and horizontal high-shear granulator. These sub-classes are primarily distinguished by the geometric positioning and orientation of the primary impellers.


A vertical high shear granulators are where the impeller shaft rotates in the vertical plane and the impellers are bladelike. The vertical high shear granulators could be either a top-driven (example Colleter-Gral granulator) or a bottom-driven unit (example Diosna or Powrex granulators).


In the horizontal high shear granulators, the impeller shaft rotates in the horizontal plane (or is said to be side driven).

Factors affecting the granulation process and granule properties of high shear granulators

  • Formulation variables; that is the type and quantities of excipients used.
  • The physical properties of the materials to be granulated.
  • The type and amount of binder solution used in the process.
  • Process variables which include;
    1. Load of the granulator bowl.
    2. Impeller speed
    3. Granulating solution addition method
    4. Granulating solution addition rate
    5. Chopper speed
    6. Wet-massing tire
    7. Granulator design.

permix High Shear granulators - advantages

  • Granulation process requires less binder solution.
  • Granulation is achieved within a short time.
  • Greater densification and production of less friable granules.
  • The granulator produces reproducible less friable granules with a uniform particle size distribution.
  • High shear granulators minimize the exposure of drug dust to workers due to reduced process dust generation.
  • Granulation endpoint is predictable while using high-shear granulator.
  • Requires short drying times.

PERMIX HIGH SHEAR GRANULATORS Downloads

PerMix High Shear Granulator Brochure (pdf)Download

permix high shear granulator Photo Gallery

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